Basseterre is a small city that is laid out in a grid pattern. It has four main streets running west to east, and they are listed here in sequence from south to north: Bay Road, Liverpool Row, Central Street, and Cayon Street. The main street running north to south is Fort Street/Bank Street, which is home to the bulk of the island's main shops and banks. The city has two centres, at The Circus, which is geared towards tourism, and the Independence Square, which contains the cathedral, courthouse, and most of the older buildings.

Basseterre is the main commercial and industrial centre of St. Kitts. It is also the country's main port of entry for both sea and air travel, as well as the road and rail transport hub. It houses the administration buildings for the federal government (those for the island of Nevis are in Charlestown). It also houses the headquarters of the Eastern Caribbean Central Bank, as well as the headquarters for many other regional financial institutions.